Súvislosť medzi subinhibičnou koncentráciou biocídov a bakteriálnou rezistenciou voči antibiotikám pre kmeň Enterococcus faecalis
Klíčová slova:biocídy, bakteriálna rezistencia, krížová rezistencia, antibiotiká
Biocides are very effective against huge spectrum of microorganisms and are used in wide range. Recent research pointed out on fact that there could be connection between use of biocides and development of antibiotic resistance. This paper assesses long-term effect of common biocides in subinhibitory concentrations on the development of antibiotic resistance in Enterococcus faecalis. We have studied effect of three common biocides – NaClO, ClO2 and H2O2/Ag. Obtained data showed, that all biocides decreased susceptibility of E. faecalis to ampicillin. In case of H2O2/Ag also gentamicin resistance has developed after long-term treatment. On the other hand, this biocide has caused loss of vancomycin resistance in E. faecalis. This suggests very important fact; however vancomycin resistant enterococci are according to WHO classified as pathogens with high priroty.