Study of Stability of 4-Aminophenol as Dominant Decomposition Product of Paracetamol

Authors

  • L. Hanysova Department of Pharmaceutical Chemistry and Drug Control, Faculty of Pharmacy, Charles University, Hradec Kralove
  • P. Kastner Department of Pharmaceutical Chemistry and Drug Control, Faculty of Pharmacy, Charles University, Hradec Kralove
  • J. Klimes Department of Pharmaceutical Chemistry and Drug Control, Faculty of Pharmacy, Charles University, Hradec Kralove

Abstract

An HPLC method for determination of very low concentrations of 4-aminophenol was elaborated, and the kinetics of its decomposition at low temperatures and at laboratory temperature in the absence of light or under irradiation at 254 nm were compared. To increase the sensitivity of the method, derivatization of 4-aminophenol with various reagents was tested. Phthalaldehyde proved to be the best; its reaction at laboratory temperature in the presence of 2-sulfanylethanol is very fast. The derivatization conditions were optimized.

Downloads

Published

2004-04-15

How to Cite

Hanysova, L., Kastner, P., & Klimes, J. (2004). Study of Stability of 4-Aminophenol as Dominant Decomposition Product of Paracetamol. Chemické Listy, 98(3). Retrieved from http://ww-w.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/2156

Issue

Vol. 98 No. 3 (2004)

Section

Articles