Stanovení stopových množství léčiv v pitných vodách metodou GC-MS

Abstrakt

The aim of this study was GC-MS  screening of drin­king water supplies for the presence of traces of pharmaceuticals.  The target analytes were naproxen, ibuprofen, diclofenac, carbamazepine and 17α-ethynylestradiol. Solid-phase extraction (SPE) was used for for their preconcetration. Derivatization of target analytes in the eluted extracts was performed using N-(tert-butyldimethylsilyl)-N-methyltrifluoroacetamide. Limits of quantification were less than 0.5 ng/L for naproxen, ibuprofen, diclofenac, carbamazepine and less than 2.0 ng/L for 17α-ethynyl­estradiol. The presence of target pharmaceuticals in drin­king water in the Czech Republic is very rare; their concentrations range on the ng/L level.