GC-MS Determination of Trace Amounts of Pharmaceuticals in Drinking Water

Authors

  • I. Pomykačová Department of Water Hygiene, National Institute of Public Health, Prague
  • V. Čadek Department of Water Hygiene, National Institute of Public Health, Prague
  • V. Svobodová Department of Water Hygiene, National Institute of Public Health, Prague
  • F. Kožíšek Department of Water Hygiene, National Institute of Public Health, Prague | Department of General Hygiene, 3rd Medical Faculty of Charles University, Prague
  • H. Jeligová Department of Water Hygiene, National Institute of Public Health, Prague

Keywords:

drinking water, pharmaceuticals, GC-MS

Abstract

The aim of this study was GC-MS  screening of drin­king water supplies for the presence of traces of pharmaceuticals.  The target analytes were naproxen, ibuprofen, diclofenac, carbamazepine and 17α-ethynylestradiol. Solid-phase extraction (SPE) was used for for their preconcetration. Derivatization of target analytes in the eluted extracts was performed using N-(tert-butyldimethylsilyl)-N-methyltrifluoroacetamide. Limits of quantification were less than 0.5 ng/L for naproxen, ibuprofen, diclofenac, carbamazepine and less than 2.0 ng/L for 17α-ethynyl­estradiol. The presence of target pharmaceuticals in drin­king water in the Czech Republic is very rare; their concentrations range on the ng/L level.

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Published

2012-02-15

How to Cite

Pomykačová, I., Čadek, V., Svobodová, V., Kožíšek, F., & Jeligová, H. (2012). GC-MS Determination of Trace Amounts of Pharmaceuticals in Drinking Water. Chemické Listy, 106(2), 143–148. Retrieved from http://ww-w.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/1001

Issue

Vol. 106 No. 2 (2012)

Section

Articles