Voltammetric Determination of Metronidazole Using a Silver Solid Working Electrode

Authors

  • O. Mráček UNESCO Laboratory of Environmental Electrochemistry, Department of Analytical Chemistry, Faculty of Science, Charles University, Prague
  • V. Vyskočil UNESCO Laboratory of Environmental Electrochemistry, Department of Analytical Chemistry, Faculty of Science, Charles University, Prague http://orcid.org/0000-0001-9465-3931

Keywords:

metronidazole, antibiotics, drug analysis, electrochemistry, differential pulse voltammetry, silver solid electrode

Abstract

Metronidazole (MND) is an antibiotic drug used to treat severe bacterial infections (e.g., of the central nervous system, lungs and respiratory tract, digestive tract, or female genital organs). In this work, a new voltammetric method for the determination of MND on a silver solid electrode was developed. Under optimum conditions (Britton-Robinson buffer of pH 10.0 used as a supporting electrolyte and electrochemical regeneration of the working electrode surface applied to eliminate its passivation), a linear calibration dependence of MND was recorded in the concentration range from 1 to 400 μmol L−1, with the limits of detection (LOD) and quantification (LOQ) of 0.55 μmol L−1 and 1.8 μmol L−1, respectively.

Full text English translation is available in the on-line version.

Published

2021-12-15

How to Cite

Mráček, O., & Vyskočil, V. (2021). Voltammetric Determination of Metronidazole Using a Silver Solid Working Electrode. Chemické Listy, 115(12), 669–672. Retrieved from http://ww-w.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/3969

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