Integrity of Film-Coated Tablets Deduced from Permeability to Gases

Authors

  • M. Veselý Department of Organic Technology, Institute of Chemical Technology, Prague
  • P. Čapek Department of Organic Technology, Institute of Chemical Technology, Prague
  • P. Diblíková Department of Organic Technology, Institute of Chemical Technology, Prague
  • A. Höferová Department of Organic Technology, Institute of Chemical Technology, Prague
  • P. Zámostný Department of Organic Technology, Institute of Chemical Technology, Prague

Keywords:

film coating, permeability, coat quality

Abstract

The integrity of film-coated tablets may be a crucial factor for their long-term stability as well as for their desi­rable action in the digestive tract. Consequently, non-destructive and sensitive tests are very important for quality control of the film-coated tablets. The quasi-stationary permeation of inert gases through the tablets was proposed as a new fast and inexpensive test of the integrity of film-coated tablets. Using the commercial coating material Opadry® and alternative coating materials, the sensitivity to the test of the coating composition and to local damage of the tablets by mechanical stress was demonstrated.

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Published

2015-01-15

How to Cite

Veselý, M., Čapek, P., Diblíková, P., Höferová, A., & Zámostný, P. (2015). Integrity of Film-Coated Tablets Deduced from Permeability to Gases. Chemické Listy, 109(1), 51–54. Retrieved from http://ww-w.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/414

Issue

Vol. 109 No. 1 (2015)

Section

Articles