Synthesis of the PET Radiopharmaceutical [¹⁸F]Fluorocholine, Development of Analytical Methods and Optimization of Dimethylaminoethanol Content in the Final Product

Authors

  • F. Kužel FNSPE CTU, Prague | ÚJV Řež, a.s., Husinec-Řež
  • A. Novotná ÚJV Řež, a.s., Husinec-Řež
  • J. Adam RECAMO – Masaryk Memorial Cancer Institute, Brno | ÚJV Řež, a.s., Husinec-Řež

Keywords:

positron emission tomography, radiopharmaceuticals, [¹⁸F] fluorocholine, analytical methods

Abstract

[18F]fluorocholine is a substance of utmost importance for prostate carcinoma diagnostics by positron emission tomography (PET). The process of synthesis, development of quality control methods and optimization of performance to fulfill strict requirements of drug control authorities for commercial production of the substance are demonstrated.

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Published

2017-09-15

How to Cite

Kužel, F., Novotná, A., & Adam, J. (2017). Synthesis of the PET Radiopharmaceutical [¹⁸F]Fluorocholine, Development of Analytical Methods and Optimization of Dimethylaminoethanol Content in the Final Product. Chemické Listy, 111(9), 604–609. Retrieved from http://ww-w.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/48

Issue

Vol. 111 No. 9 (2017)

Section

Articles