Low-molecular-weight Inhibitors of Enterovirus Replication

Authors

  • R. Nencka Institute of Organic Chemistry and Biochemistry, Prague
  • H. Hřebabecký Institute of Organic Chemistry and Biochemistry, Prague
  • M. Šála Institute of Organic Chemistry and Biochemistry, Prague
  • M. Dejmek Institute of Organic Chemistry and Biochemistry, Prague

Keywords:

enteroviruses, picornaviruses, antivirals, virus replication inhibitors

Abstract

Enteroviruses rank among the most common human pathogens; millions of people suffer from diseases caused by them every year. However, no specific treatment of infections caused by this genus from the Picornaviridae family has been introduced to clinical practice so far. Therefore, a search for potential therapeutics aiming at these viruses is urgently needed. Due to advances in biochemistry and molecular biology, we are able to aim at specific viral proteins as well as possible host factors essential for virus replication in cells. Recently, a number of compounds inhibiting replication of various enteroviruses have been reported, based on both rational target-based drug design and phenotypic screening. This article is a review of common structure patterns of the compounds that have been recently found to inhibit the replication of enteroviruses.

Published

2014-04-15

How to Cite

Nencka, R., Hřebabecký, H., Šála, M., & Dejmek, M. (2014). Low-molecular-weight Inhibitors of Enterovirus Replication. Chemické Listy, 108(4), 326–334. Retrieved from http://ww-w.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/520

Issue

Section

Articles