Brief History of Chemotherapy

Authors

  • Z. Oktábec Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno | Department of Toxicology, Institute of Forensic Medicine and Toxicology, First Faculty of Medicine, Charles University and Faculty Hospital, Prague
  • J. Jampílek Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno

Keywords:

antineoplastics, chemotherapy history, alkylating agents, antimetabolites, platinum derivatives, tyrosine kinase inhibitors

Abstract

Tumors of various etiology are considered to be one of the most frequent reasons for disorders and death. According to the WHO, cancer is a leading cause of death accounting for 7.6 million deaths (ca. 13 % of all deaths) in 2008. The present review deals with discoveries, research and development in the field of antineoplastics, spanning substances from yperite derivatives to biological therapy and tyrosine kinase inhibitors. The important milestones of the development of antitumor drugs as well as cancer chemotherapy are mentioned.

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Published

2013-02-15

How to Cite

Oktábec, Z., & Jampílek, J. (2013). Brief History of Chemotherapy. Chemické Listy, 107(2), 151–159. Retrieved from http://ww-w.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/767

Issue

Vol. 107 No. 2 (2013)

Section

Articles