Biochemical Significance of Matrix Gla Protein and Its Potential Use as a Marker in Clinical Biochemistry

Authors

  • Miloš Barna Department of Medical Chemistry and Clinical Biochemistry, Second Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic | Department of Orthopaedics, First Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic
  • Jana Čepová Department of Medical Chemistry and Clinical Biochemistry, Second Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic
  • Kateřina Dunovská Department of Medical Chemistry and Clinical Biochemistry, Second Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic
  • Pavel Melicherčík Department of Orthopaedics, First Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic
  • Vladislav Barták Department of Orthopaedics, First Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic
  • Richard Průša Department of Medical Chemistry and Clinical Biochemistry, Second Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic
  • René Kizek Department of Medical Chemistry and Clinical Biochemistry, Second Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic
  • Eva Klapková Department of Medical Chemistry and Clinical Biochemistry, Second Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic

DOI:

https://doi.org/10.54779/chl20240270

Keywords:

bone metabolism, matrix Gla proteins, levels of calcium and phosphates, biochemical markers, vitamin K2

Abstract

The aim of this work was to present an overview on the biochemical significance of the matrix γ‑carboxyglutamate (Gla) protein (MGP). According to the literature, the MGP is associated with vascular, bone, and kidney metabolisms, as well asvitamin K levels. The relationship of MGP to Keutel's syndrome, Pseudoxanthoma elasticum, colitis, and dental calculus is described. The information published so far suggests that MGP protein levels could have potential as a biochemical marker in these serious diseases.

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Published

2024-05-15

How to Cite

Barna, M., Čepová, J., Dunovská, K., Melicherčík, P., Barták, V., Průša, R., Kizek, R., & Klapková, E. (2024). Biochemical Significance of Matrix Gla Protein and Its Potential Use as a Marker in Clinical Biochemistry. Chemické Listy, 118(5), 270–276. https://doi.org/10.54779/chl20240270

Issue

Vol. 118 No. 5 (2024)

Section

Articles

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