Soft Drugs and Retrometabolic Drug Design

Authors

  • J. Tengler Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno | Medis International Co., Bolatice
  • O. Stropnický Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno

Keywords:

soft drugs, retrometabolic drug design, ultra-short acting drugs, chemical delivery systems, therapeutic index

Abstract

The soft drug concept involves a possible way of developing safer drugs with broad therapeutic index. A metabolically labile group, usually an ester group, is introduced into the structure of the drugs. Hydrolysis of this group by the action of blood and tissue esterases leads rapidly to the inactive intermediates after reaching a desired effect. This review deals with brief history, termino­logy and most important and promising representatives of this group.

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Published

2014-01-15

How to Cite

Tengler, J., & Stropnický, O. (2014). Soft Drugs and Retrometabolic Drug Design. Chemické Listy, 108(1), 25–31. Retrieved from http://ww-w.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/568

Issue

Vol. 108 No. 1 (2014)

Section

Articles